Kolwezi or Kolwesi is the capital city of Lualaba Province in the south of the Democratic Republic of the Congo, west of Likasi. It is home to an airport and a railway to Lubumbashi. Just outside of Kolwezi there is the static inverter plant of the HVDC Inga-Shaba. The population is approximately 573,000.

Before the creation of Lualaba province in 2015 Kolwezi had two territories attached to it and the whole was known as the Kolwezi District.

Kolwezi is an important mining centre for copper and cobalt. There are also uranium, radium, oxide ores, and lime deposits. The Musonoi mine is a set of open-cut pits near Kolwezi from which copper and other metals have been extracted since the 1940s. The nearby Lake Nzilo was created by damming the Lualaba River to provide a source of hydroelectric power and a reservoir of water for the mining activities.